22. Mezioborová toxikologická konference

22nd Interdisciplinary Toxicological Conference

TOXCON 2017

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Abstracts:

All authors are requested to submit an abstract (up to 350 words) of their contribution by an e-mail before May 18, 2017. The abstract should include the title of the paper (in bold capital letters) followed by the name(s) of the author(s) and affiliation(s), underlining the presenting author. This is followed by the main text and acknowledgements.

Abstract sample:

TRACE ELEMENTS STATUS IN SELENIUM-DEFICIENT RATS–INTERACTION WITH CADMIUM
Kotyzová D.1, Černá P.1, Lešetický L.2, Eybl V.1
1 Department of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; 2 Department of Organic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic


Although the metabolic and toxicological interactions between essential element selenium (Se) and toxic element cadmium (Cd) have been reported for a long time, the experimental studies explored mostly acute, high-dose interactions. Limited data are available regarding the effects of Se-deficiency on toxicokinetics of cadmium, as well as on the levels of key trace elements--copper, zinc, and iron. In the present study, male and female Wistar weanling rats (n = 40/41) were fed either Se-deficient or Se-adequate diet (<0.06 or 0.14 mg Se per kilogram diet, respectively) for 12 weeks, and from week 9 were drinking water containing 0 or 50 mg Cd/l as cadmium chloride. At the end of the 12-week period, trace element concentrations were estimated by AAS. Selenium-deficient rats of both genders showed significantly lower accumulation of cadmium in the liver, compared to Se-adequate rats. Zinc and iron hepatic levels were not affected by Se-deficiency. However, a significant elevation of copper was found in the liver of Se-deficient rats of both genders. Cadmium supplementation increased zinc and decreased iron hepatic level, regardless of Se status and decreased copper concentration in Se-adequate rats. Se-deficiency was also found to influence the effectiveness of cadmium mobilization in male rats.
Supported by the research grant MSM 0021620819 of the Ministry of Education of the Czech Republic.

Abstract Submission Deadline:    May 18, 2017, dana.kotyzova@lfp.cuni.cz