22. Mezioborová toxikologická konference

22nd Interdisciplinary Toxicological Conference

TOXCON 2017

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Wednesday, June 21, 2017

13.00 - 19.00Registration

15.00 - 15.45Official Opening of TOXCON 2017

Welcoming Address
The session in honour of Prof. Vladislav Eybl, doc. Koutenský and RNDr. Zdeněk Zídek for their lifelong scientific work

15.45 - 17.00Session 1:  Pharmacotoxicology
Chairpersons:Michal Dubovický, Pavel Suchý

L-01  TO THE TRANSPORT OF XENOBIOTIC INTO SYNOVIAL FLUID (EXPERIMENTAL MODEL: MINIPIGS)
Květina J.1, 2, Nobilis M.3
1Department of Human Pharmacology and Toxikology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; 2Department of Internal Medicine - Gastroenterology, University Hospital, Hradec Králové, Czech Republic; 3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic

L-02  POSSIBILITIES OF STIMULATION OF LIVER PARENCHYMA REGENERATION IN CONNECTION WITH PLANNED EXTENDED SURGICAL PROCEDURE – EXPERIMENT ON LARGE ANIMAL AND ITS IMPORTANCE FOR HUMAN SURGERY
Liska V.1, Treska V.1, Mirka V. 2, Bruha J.1, Vycital O.1, Haidingerova L.3, Palek R.1, Rosendorf J.1
1Department of Surgery, 2Department of Radiology, 3Department of Anaesthesiology and Resuscitation, Teaching Hospital and Medical School in Pilsen, Charles University

L-03  2-(3-METHOXYPHENYL)QUINAZOLINE DERIVATIVES: A NEW CLASS OF DIRECT CONSTITUTIVE ANDROSTANE RECEPTOR (CAR) AGONISTS
Smutny T.1, Nova A.3, Drechslerová M.2, Carazo A.1, Hyrsova L.1, Hrušková Z.R.2, Kuneš J.2, Pour M.2, Špulák M.2, Pavek P.1
1Department of Pharmacology and Toxicology, 2Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, Hradec Kralove CZ-500 05, Czech Republic, 3Institute of Molecular and Translation Medicine, Faculty of Medicine, Palacky University in Olomouc, Hnevotinska 5, CZ-779 00 Olomouc, Czech Republic

L-04  THE PREGNANE X RECEPTOR DOWN-REGULATES ORGANIC CATION TRANSPORTER 1 (SLC22A1) IN HUMAN HEPATOCYTES BY COMPETING FOR ("SQUELCHING") SRC-1 COACTIVATOR
Hyrsova L.1, Smutny T.1, Carazo A.1, Moravcik S.1, Mandikova J.1, Trejtnar F.1, Gerbal-Chaloin S.2, 3, Pavek P.1
1Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, CZ-500 05, Czech Republic; 2INSERM, U1183, Institute for Regenerative Medicine and Biotherapy, Montpellier, France; 3Université de Montpellier, Montpellier, France.

17.00 - 17.30COFFEE BREAK

17.30 - 18.30Poster Presentations

19.30 - 21.00Welcome Drink and Dinner

Thursday, June 22, 2017

8.45 - 10.00Session 2:  Cytotoxicity, Carcinogenicity & Genotoxicity
Chairpersons:Ingrid Brucknerová, Eva Kmoníčková

L-05  BISFENOL S: ENDOCRINE DISRUPTING EFFECT OF EXTREMELY LOW DOSES ON MICE OVARIES
Nevoral J.1, 2, Kolinko Y.1, 2, Kochová K.1, 2, Benešová K.1, 2, Klein P.1, Tonar Z.1, 2, Žalmanová T.3, Hošková K.3, Petr J.4, Králíčková M.1, 2
1Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic 2Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic, 3Department of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic, 4Institute of Animal Science, Prague 10-Uhrineves, Czech Republic

L-06  APOFERRITIN NANOCARRIER WITH ENCAPSULATED ELLIPTICINE – ITS CONSTRUCTION AND PROPERTIES
Indra R.1, Wilhelm M.1, Černá T.1, Heger Z.2, Dostálová S.2, Adam V.2, Eckschlager T.3, Stiborová M.1
1Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic; 2Department of Chemistry and Biochemistry, Laboratory of Metallomics and Nanotechnology, Mendel University in Brno, Zemedelska 1, 61300 Brno, Czech Republic; 3Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84/1, 150 06 Prague 5, Czech Republic

L-07  NOVEL TAXANES; EFFICACY AND MOLECULAR MECHANISM OF ACTION IN EXPERIMENTAL MODELS AND CANCER PATIENTS
Vaclavikova R1, 2, Ehrlichova M1, 2, Mohelnikova-Duchonova B.3, Wang C4, Su, Y4, Ojima I4, Brynychova V1, 2, Elsnerova K.1, 2, Kristensen VN.5 and Soucek P1, 2
1Laboratories of Toxicogenomics, National Institute of Public Health in Prague, Czech Republic; 2Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; 3Department of Oncology, Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic; 4Institute of Chemical Biology & Drug Discovery, State University of New York at Stony Brook, USA; 5Institute of Clinical Epidemiology and Molecular Biology (EpiGen), Akershus University Hospital, Oslo, Norway

L-08  TRIOORGANOTIN COMPOUNDS, COGNATE LIGANDS, OF NUCLEAR RETINOID X RECEPTORS – BIOLOGICAL EFFECTS IN HUMAN BREAST CANCER CELL LINES
Brtko J.1, Toporová L.1, Macejová D.1, Hunáková L.2, Bobálová J.3
1Institute of Experimental Endocrinology, BMC, SAS, Bratislava, Slovakia; 2Cancer Research Institute, BMC, SAS, Bratislava, Slovakia; 3Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic

10.00 - 10.30COFFEE BREAK

10.30 - 11.50Session 3:  Regulatory Toxicology & Legislation
Chairpersons:Daniela Pelclová, Mojmír Mach

L-09  PHARMACOVIGILANCE AND THE IMPORTANCE OF ADVERSE DRUG REACTIONS REPORTING
Jirsová E.
Pharmacovigilance Department, State Institute for Drug Control, Prague, Czech Republic

L-10  PHOTOALLERGY TO KETOPROFEN: MINIMIZING A RISK OF A WELL-KNOWN ADVERSE REACTION
Tobolka R.
Pharmacovigilance Department, State Institute for Drug Control, Prague, Czech Republic

L-11  ADVERSE DRUG REACTIONS TO VACCINES
Kaftanová P.
Pharmacovigilance Department, State Institute for Drug Control, Prague, Czech Republic

L-12  “GOLDEN EGGS” AND DRUG ABUSE
Holubová A.
Pharmacovigilance Department, State Institute for Drug Control, Prague, Czech Republic

11.50 - 13.00LUNCH

13.00 - 14.20Session 4:  Drug Abuse and Forensic Toxicology
Chairpersons:Marie Balíková, Jiří Kassa

L-13  DEXTROMETHORPHAN – ABUSE BY ADOLESCENS
Kovářová L.
Pharmacovigilance Department, State Institute for Drug Control, Prague, Czech Republic

L-14  DXM – OVER THE COUNTER PSYCHOACTIVE SUBSTANCE, THAT ARE WELL KNOWN TO CHILDREN, BUT LESS KNOWN TO PARENTS AND MEDICAL PROFFESIONALS
Rábová G.1, Vevera J.1, Hudeček J.1, Podlipný J.1, Kmoch V.2, Kovářová L.3, Lacinová E.4
1Psychiatrická klinika FN Plzeň a Lékařská fakulta UK v Plzni, 2Klinika adiktologie 1. LF UK a VFN Praha, 3Státní ústav pro kontrolu léčiv Praha 2Klinika pracovního lékařství a VFN Praha, Czech Republic

L-15  NEW PSYCHOACTIVE SUBSTANCES IN TOXICOLOGICAL PRACTICE
Židková M., Balíková M.
Institute of Forensic Medicine and Toxicology, 1st Medical Faculty, Charles University and General University Hospital, Ke Karlovu 2, 128 08 Prague

L-16  DETECTION OF PARA-FLUOROFENTANYL IN FATALITY
Marešová V., Sladká Z., Pilin A.
Institute of Forensic Medicine and Toxicology, First Faculty of Medicine in Prague, Charles University and General University Hospital, Prague, Czech Republic

14.20 - 14.40COFFEE BREAK

14.40 - 15.40Session 5:  Food Toxicology and Immunotoxicology
Chairpersons:Govindan Dayanithi, Petr Hodek

L-17  LEUKOTRIENE-MEDIATED NEUROINFLAMMATION IN THE MECHANISMS OF METHANOL NEUROTOXICITY
Zacharov S.1, 2, Kotikova K.1, Nurieva O.1, Kacer P.3, Navratil T.2, 4, Pelclova D.1, 2
1First Faculty of Medicine, Charles University, Department of Occupational Medicine, Prague, Czech Republic; 2Toxicological Information Centre, General University Hospital, Prague, Czech Republic; 3Institute of Chemical Technology, Prague, Czech Republic; 4Department of Biomimetic Electrochemistry, J. Heyrovský Institute of Physical Chemistry of the AS CR, v.v.i, Prague, Czech Republic

L-18  EFFECT OF ETHANOL ON THE HYPOTHALAMIC VASOPRESSIN AND OXYTOCIN RELEASE AND ON THE SPONTANEOUS CALCIUM OSCILLATIONS IN THE SUPRAOPTIC NUCLEUS NEURONS AND NERVE TERMINALS
Dayanithi G.1, 2 , 3
1Department of Molecular Neurophysiology, Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, CZ-14220 Prague, Czech Republic; 2Department of Pharmacology and Toxicology, Faculty of Medicine in Plzen, Charles University, Czech Republic; 3Institut National de la Santé et de la Recherche Médicale-U1198, Ecole Pratique des Hautes Etudes, Université de Montpellier, F-34095Montpellier, France

L-19  ANTIBODY PROPHYLAXIS OF CF LUNG MICROBIAL INFECTIONS
Hodek P.1, Vašková L.1, Rychnová J.1, Kubíčková B.1, Dostálová K.1, Wimmerová M. 2, Stiborová M.1
1Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic; 2Department of Biochemistry, Faculty of Science, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic

15.40 - 16.00COFFEE BREAK

16.00 - 17.00Poster Presentations

17.15 - 19.00Pilsner Urquell Brewery Tour (facultative)

19.30Social Evening: Pilsner Restaurant ”Na Spilce”

Friday, June 23, 2017

09.00 - 11.00Session 6:  Metabolism of Xenobiotics, Occupational Toxicology
Chairpersons:Pavel Anzenbacher, Stanislav Yanev

L-20  TOXICOLOGICAL IMPORTANCE OF IMMUNE SYSTEM/DRUG METABOLISM INTERACTIONS
Yanev S. G.
Department Drug Toxicology, Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria

L-21  CHRONIC HEALTH IMPAIRMENT AND ELIMINATION HALF-LIFE 50 YEARS FOLLOWING 2,3,7,8-TETRACHLORO-DIBENZO-P-DIOXIN EXPOSURE
Pelclova D., Fenclova Z., Navratil T., Vlckova S., Urban P., Ridzon P., Zakharov S.
Charles University, First Faculty of Medicine and General University Hospital, Department of Occupational Medicine, Prague, Czech Republic

L-22  3-NITROBENZANTHRONE, A POTENT ENVIRONMENTAL MUTAGEN AND CARCINOGEN, FORMS A NEW TYPE OF ADDUCT WITH CYSTEINE IN GLOBIN AND PLASMA PROTEINS
Linhart I.1, Hanzlíková I.2, Mráz J.2, Dušková Š.2, Dabrowská L.2, Chrástecká H.2, Vajtrová R.2, Tvrdíková M.2
1Department of Organic Chemistry, University of Chemistry and Technology, Prague;
2National Institute of Public Health, Prague

L-23  THE POTENTIAL TOXICITY OF THE DENTAL AMALGAM
Bučková L.
Department of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic

L-24  ARSENIC COMPOUNDS: THEIR TOXICITY AND CLINICAL IMPLICATIONS
Kmoníčková E., Kotyzová D., Bludovská M., Eybl V.
Department of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic

11.00 - 11.20Closing of the Conference

11.20 - 12.00LUNCH